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US 11,685,750 B2Granted
Crystalline forms of IRAK degraders
AssigneeKymera Therapeutics, Inc.
InventorsXiaozhang Zheng, Don Corson
Life of this patent
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Abstract
The present disclosure relates generally to various forms, salts and compositions of compounds useful for the modulation of one or more interleukin-1 receptor-associated kinases (“IRAK”) via ubiquitination and/or degradation and uses of the same in the treatment various diseases.
Claims29
A crystalline solid form of compound 1:
- wherein the crystalline solid form is selected from the group consisting of Form A of compound 1 and Form B of compound 1;
- and wherein:
- Form A of compound 1 is characterized by three or more peaks in its X-ray powder diffraction pattern selected from those at about 6.0, about 16.5, about 17.2, about 23.0, and about 23.9 degrees 2-theta;
- and
- Form B of compound 1 is characterized by three or more peaks in its X-ray powder diffraction pattern selected from those at about 3.2, about 16.2, about 16.5, about 17.1, and about 18.2 degrees 2-theta.
2 more elements
A crystalline salt form of compound 1:
- selected from the group consisting of:
- and
- wherein:
- the crystalline salt form of compound 2 is Form A of compound 2;
- the crystalline salt form of compound 3 is Form A of compound 3;
- the crystalline salt form of compound 4 is Form A of compound 4;
- and
- wherein:
- Form A of compound 2 is characterized by three or more peaks in its X-ray powder diffraction pattern selected from those at about 14.1, about 17.0, about 17.3, about 19.0, about 21.0, about 21.2 and about 23.3 degrees 2-theta;
- Form A of compound 3 is characterized by three or more peaks in its X-ray powder diffraction pattern selected from those at about 6.4, about 11.9, about 16.2, about 17.2, and about 20.9 degrees 2-theta;
- and
- Form A of compound 4 is characterized by three peaks in its X-ray powder diffraction pattern at about 3.3, about 6.4, and about 16.7 degrees 2-theta.
9 more elements
Dependencies are inferred from the claim text.