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US 11,685,741 B2Granted
Fluorescent probes
AssigneeUniversity of Massachusetts
InventorMaolin Guo
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.
Claims3
A compound of Formula III:
- or a salt thereof, wherein
- is a single or double bond;
- Xb is O;
- Yb is O;
- L1b is a bond;
- L3b is (CRz)u;
- u is 2;
- L2b is (CH)3;
- Zb is N;
- ring B is selected from C6-10 aryl and 5-10 membered heteroaryl;
- ring Ab is selected from C6-10 aryl and 5-10 membered heteroaryl;
- each Rz is independently selected from H and C1-6 alkyl;
- each R8b is independently NRc1Rd1;
- each R10b is independently C1-6 alkyl;
- R11b and R12b are each C1-6 alkyl;
- Rc1 and Rd1 are each independently selected from C1-6 alkyl;
- v is 1, 2, or 3;
- and
- w is 1, 2, or 3.
16 more elements
Dependencies are inferred from the claim text.