Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same

A method for treating stroke or depression, comprising administering an effective amount of a compound represented by Formula (I):

• wherein
• Z1 is N;
• Z2 is C(R5a)(R5a′) or N(R5b);
• the dashed line represents the presence or absence of a bond;
• when the dashed line represents the presence of a bond, then R5a′ and R5b are absent;
• R5a is a hydrogen atom, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylamino, substituted or unsubstituted alkenylamino, substituted or unsubstituted alkynylamino, substituted or unsubstituted aromatic carbocyclyl, or substituted or unsubstituted aromatic heterocyclyl;
• R5a′ is a hydrogen atom;
• R5b is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• Ring Q is a substituted or unsubstituted 5-membered non-aromatic heterocycle or a substituted or unsubstituted 6-membered non-aromatic heterocycle;
• Y1 is O;
• R2a is a represented by the formula:
• —(C(R2a′)(R2b′)(R2b′))n—R1;
• R2b is a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R2a′ is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R2b′ is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R2a′ and R2b′ which are attached to the same carbon atom may be taken together to form oxo;
• R1 is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• X is N(R7a);
• R7a is a hydrogen atom, substituted or unsubstituted alkyl, or substituted or unsubstituted alkylcarbonyl;
• R2c is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R2d is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R2c and R2d which are attached to the same carbon atom may be taken together to form a substituted or unsubstituted non-aromatic carbocycle, or two of R2c may be taken together to form a substituted or unsubstituted non-aromatic carbocycle;
• R3 is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• n is an integer from 0 to 4;
• and
• m is an integer from 0 to 4,
• or a pharmaceutically acceptable salt thereof, to a patient in need thereof.