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US 11,685,729 B2Granted
C5a receptor modulators
AssigneeIdorsia Pharmaceuticals Ltd
InventorsSylvie Froidevaux, Francis Hubler, Mark Murphy, Dorte Renneberg, Simon Stamm
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Abstract
The present invention relates to derivatives of formula (I) wherein Ring A, W, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
Claims18
A compound of formula (I)
- wherein
- W represents N, or CR5 wherein R5 represents hydrogen or (C1-3)alkoxy;
- and
- X, Y and Z independently represent CH or N;
- ring A represents an unsubstituted, saturated 4- to 7-membered mono-cyclic carbocyclic ring containing the ring nitrogen atom to which R1 is attached;
- R1 represents phenyl;
- 5-membered heteroaryl;
- or 6-membered heteroaryl;
- wherein said phenyl, 5-membered heteroaryl or 6-membered heteroaryl independently is mono-, di- or tri-substituted, wherein the substituents are independently selected from
- (C1-4)alkyl;
- (C1-4)alkoxy;
- (C1-3)fluoroalkyl;
- (C1-3)fluoroalkoxy;
- halogen;
- cyano;
- (C3-6)cycloalkyl;
- R2 represents phenyl;
- 5-membered heteroaryl;
- or 6-membered heteroaryl;
- wherein said phenyl, 5-membered heteroaryl, or 6-membered heteroaryl independently is mono-, or di-substituted, wherein the substituents are independently selected from
- (C1-4)alkyl;
- (C1-4)alkoxy;
- (C1-3)fluoroalkyl;
- (C1-3)fluoroalkoxy;
- halogen;
- hydroxy-(C2-3)alkoxy;
- (C1-3)alkyl-carbonyl-oxy-(C2-3)alkoxy;
- cyano-(C1-2)alkoxy;
- (C3-6)cycloalkyl-X21—, wherein X21 represents a direct bond, —O—, or —(C1-3)alkylene-O—, and wherein the (C3-6)cycloalkyl independently contains one optional ring oxygen atom;
- or
- R21aR21bN—(C2-3)alkylene-O—, wherein R21a and R21b independently represent hydrogen or (C1-4)alkyl;
- R3 represents hydrogen, (C1-3)alkyl, or (C1-3)alkoxy-carbonyl;
- and
- R4 represents hydrogen, or (C1-4)alkyl;
- or a pharmaceutically acceptable salt thereof.
32 more elements
Dependencies are inferred from the claim text.