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US 11,685,720 B2Granted
Salt forms of URAT-1 inhibitors
AssigneeInventisbio Co., Ltd.
InventorsXing Dai, Yueheng Jiang
Life of this patent
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Abstract
Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to thiobutyrate compounds, such as Compound (1) and its salts (such as sodium, potassium, and calcium salt), as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as gout and hyperuricemia.
Claims19
A crystalline form I of Compound 1,
- wherein the crystalline form I is characterized by an X-ray powder diffraction (XRPD) pattern having three or more of the following peaks:
- 7.0, 10.2, 10.6, 14.0, 20.4, 21.9, 23.4, 24.9, and 25.9 degrees 2 theta, ±0.2°.
A crystalline form III of Compound 1-K,
- wherein the crystalline form III is characterized by an X-ray powder diffraction (XRPD) pattern having three or more of the following peaks:
- 8.3, 14.5, 14.8, 15.6, 16.7, 17.0, 18.2, 19.6, 20.2, 22.2, 22.6, and 25.1 degrees 2 theta, ±0.2°.
A crystalline form IV of Compound 1-Ca,
- wherein the crystalline form IV is characterized by an X-ray powder diffraction (XRPD) pattern having three or more of the following peaks:
- 4.4, 6.5, 9.1, 12.3, 13.0, 13.4, 13.7, 14.5, 16.0, 16.8, 18.2, 19.8, 21.0, and 21.6 degrees 2 theta, ±0.2°.
Dependencies are inferred from the claim text.