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US 11,685,713 B2Granted
Small molecule SHC blockers used for treating liver disease and metabolic disease
AssigneeButo Corporation
InventorsGino Cortopassi, Alexey Tomilov, Dmytro Kovalskyy
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Abstract
The subject matter disclosed herein is directed to novel She inhibitors of Formula (II). These compounds are useful for treating impaired insulin sensitivity, glucose tolerance, obesity, diabetes, metabolic syndrome, NAFLD, NASH, PSC, PBC, or other metabolic syndrome component conditions.
Claims16
A compound of Formula II:
- wherein,
- Ring M, J, J′, q, and w form
- wherein J′ is naphthalenyl, w is 1, and q is 0;
- P is a bond;
- D is absent;
- G is C═O;
- R5 is selected from the group consisting of hydrogen, hydroxyl, and linear or branched C1-C3 alkyl;
- R6 is selected from the group consisting of alkyl-S(O)m, haloalkyl-S(O)m, alkenyl-S(O)m, alkynyl-S(O)m, cycloalkylalkyl-S(O)m, aryl-S(O)m, arylalkyl-S(O)m, heterocycloalkyl-S(O)m, and heteroaryl-S(O)m, wherein S in —S(O)m is optionally substituted 1 to 3 times, in each instance, with arylalkyl, aryl, heterocyclo, or heteroaryl;
- and
- m is 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound of Formula II:
- wherein,
- Ring M, J, J′, q, and w form
- wherein J′ is pyrrolyl, w is 1, and q is 0;
- P is a bond;
- D is absent;
- G is C═O;
- and
- R5 and R6 are taken together with the nitrogen to which they are attached to form a morpholinyl ring, wherein said morpholinyl ring is substituted with aryl, and wherein said aryl is substituted 1 to 3 times, in each instance, with branched or linear alkyl, alkoxy, or haloalkoxy;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.