Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation
AssigneeInovio Pharmaceuticals, Inc.
InventorsPaul Fisher, Kate Broderick, Jay McCoy
Life of this patent
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Abstract
A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.
Claims21
An electroporation device for use with a fold of tissue, the fold of tissue including a skin layer, an adipose layer, and a smooth muscle layer, the electroporation device including:
- a frame;
- a first arm and a second arm each extending from the frame;
- a first electrode coupled to a distal end of the first arm, the first electrode having a first contact surface defining a first perimeter;
- and
- a second electrode coupled to a distal end of the second arm, the second electrode having a second contact surface defining a second perimeter, wherein the first contact surface and the second contact surface face each other and define a treatment zone therebetween for communicating an electroporation signal to the fold of tissue, the first and second contact surfaces each have an electrically insulated portion and an electrically non-insulated portion, and the electrically insulated portion is located distally of the electrically non-insulated portion and extends to the distal end of the respective first and second contact surface.
A hand-held electroporation device, comprising:
- a frame;
- a first plate electrode coupled to the frame, the first plate electrode having a first contact surface;
- and
- a second plate electrode coupled to the frame, the second plate electrode having a second contact surface that faces the first contact surface, wherein the first and second contact surfaces are configured to grip a fold of tissue, the first and second contact surfaces defining a treatment zone therebetween for communicating an electroporation signal to the fold of tissue,
- wherein the first and second contact surfaces each have an electrically insulated portion and an electrically non-insulated portion, and the electrically insulated portion is located distally of the electrically non-insulated portion and extends to the distal end of the respective first and second contact surface.
Dependencies are inferred from the claim text.