Medical connectors having integrated adhesive backing

A holder for securing a venous access device to a patient, the holder comprising:

• a flexible substrate having an upper surface, a lower surface, and an outer perimetal surface between the upper and lower surfaces;
• an adhesive layer overlaying the lower surface of the flexible substrate, the adhesive layer having an adhesive for adhering to skin of the patient;
• a hydrophilic matrix integrated into at least a portion of the adhesive layer;
• at least one solvent reservoir, disposed on the upper surface of the flexible substrate, an aperture between the at least one solvent reservoir and the adhesive layer, and a reservoir base obstructing the aperture, wherein the reservoir base is removable from the at least one solvent reservoir to permit movement of a solvent from the at least one solvent reservoir to the adhesive layer;
• and
• a connector secured to the outer perimetal surface, the connector comprising a first end for connection to a needle assembly and a second end for connection to an IV fluid line.