Silk fibroin biocompatible polyurethane membranes
AssigneesEar Science Institute Australia, Deakin University
InventorsMarcus Atlas, Benjamin Allardyce, Rodney Dilley, Rangam Rajkhowa
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Abstract
The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.
Claims16
A silk fibroin biocompatible polyurethane membrane matrix for use as a tympanic membrane, or as a scaffold for the regeneration of a tympanic membrane, wherein the membrane matrix:
- (a) includes a blend of silk fibroin and at least 90% w/w biocompatible polyurethane;
- (b) transmits sound waves between 20 Hz and 20 KHz to the middle ear in vivo;
- and
- (c) has a tensile strength between 5 MPa to 100 MPa.
The silk fibroin biocompatible polyurethane membrane matrix according to claim further comprising a plurality of membrane matrices.
A silk fibroin biocompatible polyurethane membrane matrix comprising a blend of silk fibroin and
- at least 90% w/w of a biocompatible polyurethane comprising a dihydroxypropyl poly(dimethylsiloxane) moiety,
- wherein the membrane matrix transmits sound waves between 20 Hz and 20 KHz to the middle ear in vivo and has a tensile strength between 5 MPa and 100 MPa.
Dependencies are inferred from the claim text.