Method of detecting eosinophil degranulation in the respiratory tract
AssigneeUniversity of Utah Research Foundation
InventorsLeonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
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Abstract
Disclosed are methods of detecting eosinophil degranulation in the respiratory tract of subjects. Also, disclosed are methods of producing medical images of the respiratory tract of subjects. The method can include administering radiolabeled heparin to the respiratory tract of subjects, wherein the radiolabeled heparin binds to one or more eosinophil granule protein in the mucosal tissue of the respiratory tract.
Claims12
A method of detecting eosinophil degranulation in a respiratory tract passage of a subject, the method comprising:
- administering radiolabeled heparin to the respiratory tract passage of the subject, wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the respiratory tract passage;
- and
- detecting the radiolabeled heparin in the mucosal tissue of the respiratory tract passage by one of single-photon emission computed tomography (SPECT), positron emission tomography (PET), conventional or computed tomography (CT), magnetic resonance imaging (MRI), or combinations thereof, hereby wherein detecting the radiolabeled heparin in the mucosal tissue is indicative of eosinophil degranulation in the respiratory tract passage of the subject.
A method of producing a medical image of a respiratory tract passage of a subject, the method comprising:
- administering radiolabeled heparin to the respiratory tract passage of the subject, wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the respiratory tract passage;
- and
- detecting the radiolabeled heparin by one of single-photon emission computed tomography (SPECT), positron emission tomography (PET), conventional or computed tomography (CT), magnetic resonance imaging (MRI), or combinations thereof, thereby producing a medical image of the respiratory tract passage of the subject.
Dependencies are inferred from the claim text.