AAV-mediated expression using a synthetic promoter and enhancer
AssigneeUniversity of Iowa Research Foundation
InventorsJohn F. Engelhardt, Ziying Yan
Life of this patent
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Abstract
An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods of using the vector, are provided.
Claims15
An isolated recombinant parvovirus vector comprising a synthetic enhancer operably linked to a promoter, wherein the enhancer and promoter have a sequence having at least 90% nucleotide sequence identity to SEQ ID NO:27.
An isolated vector comprising a synthetic enhancer operably linked to a promoter, wherein the enhancer and promoter have a sequence having at least 90% nucleotide sequence identity to SEQ ID NO:27.
A recombinant adeno-associated vector comprising:
- (i) an enhancer operably linked to a promoter, wherein the enhancer and promoter comprise the sequence of SEQ ID NO:27;
- and (ii) a human CFTRΔR transgene operably linked to the promoter.
Dependencies are inferred from the claim text.