Peptides and antibodies for the removal of biofilms
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLauren O. Bakaletz, Steven D. Goodman
Life of this patent
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Abstract
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.
Claims26
An isolated antibody or antigen binding fragment comprising:
- (a) a heavy chain (HC) variable domain comprising a complementarity determining region H1 (CDRH1) as set forth in SEQ ID NO:
- 58, a complementarity determining region H2 (CDRH2) as set forth in SEQ ID NO:
- 62, and a complementarity determining region H3 (CDRH3) as set forth in SEQ ID NO:
- 77;
- and
- (b) a light chain (LC) variable domain comprising a complementarity determining region L1 (CDRL1) as set forth in SEQ ID NO:
- 79, a complementarity determining region L2 (CDRL2) as set forth in SEQ ID NO:
- 82, and a complementarity determining region L3 (CDRL3) as set forth in SEQ ID NO:
- 108.
Dependencies are inferred from the claim text.