Attenuating bacterial virulence by attenuating bacterial folate transport
OwnerAlaina Ingebritson, Axel Neubauer +2inventors
InventorsAlaina Ingebritson, Axel Neubauer, Hilda Elizabeth Smith, Astrid De Greeff
Life of this patent
Estimating the term…
Abstract
The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.
Claims11
A recombinant ΔFolT mutant of a Streptococcus suis (S. suis) bacterium having reduced capacity to transport folate compared to wild type, wherein said capacity has been reduced by deletion or inactivation of a gene of the S. suis encoding folate transporter (FolT) function.
Dependencies are inferred from the claim text.