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US 11,684,662 B2Granted
Tetanus toxoid and CCL3 improve DC vaccines
AssigneeDuke University
InventorsJohn H Sampson, Duane A Mitchell, Kristen A Batich, Michael D Gunn
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AssigneeDuke University
InventorsJohn H Sampson, Duane A Mitchell, Kristen A Batich, Michael D Gunn
Estimating the term…
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific DC vaccines. Patients given Td had enhanced DC migration bilaterally and significantly improved survival. In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumor growth in a manner dependent on the chemokines CCL3 and CCL21 and Td-activated CD4+ T cells. Interference with any component of this axis markedly reduced Td-mediated DC migration and antitumor responses. Our clinical studies and corroborating investigations in mice suggest that pre-conditioning with a potent recall antigen represents a viable strategy to increase DC homing to lymph nodes and improve antitumor immunotherapy.
A method of immunizing a human, comprising:
A method of immunizing a human, comprising:
A method of immunizing a human with cancer, comprising:
Dependencies are inferred from the claim text.