Human PD1 peptide vaccines and uses thereof
AssigneesOhio State Innovation Foundation, Mayo Foundation for Medical Education and Research
InventorsPravin T. P. Kaumaya, Tanios Bekaii-Saab
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions related to synthetic PD-1 peptides, chimeric PD-1 peptides, anti-PD-1 antibodies and methods of treating cancers, autoimmune diseases, and Alzheimer's disease using said peptides or antibodies.
Claims15
An isolated peptide consisting of the amino acid sequence of SEQ ID NO:
- 5.
An isolated chimeric peptide consisting of the amino acid sequence of SEQ ID NO:
- 11.
An isolated chimeric peptide comprising the amino acid sequence of SEQ ID NO:
- 11.
An isolated chimeric peptide consisting of the amino acid sequence of i) SEQ ID NO:
- 5;
- ii) a peptide linker consisting of the amino acid sequence of SEQ ID NO:
- 7;
- and iii an amino acid sequence selected from SEQ ID NO:
- 6, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, and SEQ ID NO:
- 26;
- wherein said amino acid sequence of SEQ ID NO:
- 7 adjoins the amino acid sequence of SEQ ID NO:
- 5 to the other amino acid sequence.
An isolated chimeric peptide comprising the amino acid sequence of SEQ ID NO:
- 5 and an amino acid sequence selected from SEQ ID NO:
- 6, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, and SEQ ID NO:
- 26, wherein said amino acid sequences are adjoined via a peptide linker consisting of the amino acid sequence of SEQ ID NO:
- 7.
A method for treating a cancer in a human subject, said method comprising administering to said human subject having cancer a composition comprising a chimeric peptide comprising the amino acid sequence of SEQ ID NO:
- 5 and an amino acid sequence selected from SEQ ID NO:
- 6, wherein said amino acid sequences are adjoined via a peptide linker consisting of the amino acid sequence of SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.