Targeted delivery system, system components, and methods
AssigneeRegents of the University of Minnesota
InventorsSwayam Prabha, Tanmoy Sadhukha, Buddhadev Layek
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Abstract
A method for targeted delivery of cargo to a target locus in a subject and components of the system. Generally, the method includes administering to the subject a cell that has an artificial saccharide-derived target presented on the surface of the cell, allowing the cell to localize to a target locus in the subject, then administering to the subject an agent that specifically binds to the artificial target. In some embodiments, the agent can include a therapeutic compound. In some embodiments, the agent can include a detectable label. In some of these embodiments, that method can further include detecting the detectable label.
Claims12
A therapeutic delivery system comprising:
- a glycoengineered, undifferentiated mesenchymal stem cell capable of selectively accumulating in a tumor, the glycoengineered, undifferentiated mesenchymal stem cell comprising an artificial surface saccharide, the artificial surface saccharide comprising a reactive functional group;
- and
- a therapeutic agent comprising a functional group that is reactive with the reactive functional group;
- with the proviso that the glycoengineered stem cell does not comprise a targeting antibody.
Dependencies are inferred from the claim text.