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US 11,684,625 B2Granted
Compounds for the treatment, alleviation or prevention of disorders associated with tau aggregates
AssigneeAC Immune SA
InventorsSreenivasachary Nampally, Emanuele Gabellieri, Jerome Molette
Life of this patent
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Abstract
The present invention relates to novel compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).
Claims12
A compound of formula (I):
- (I)
- or stereoisomers, racemic mixtures, tautomers, pharmaceutically acceptable salts, thereof;
- wherein
- A is selected from the group consisting of
- wherein
- can be attached to the N atom at any available position;
- B is NRa;
- E and V are independently selected from the group consisting of N, NR5, O and S;
- G is selected from the group consisting of a benzene ring and a pyridine ring;
- Y, Y1, Y2 and Y3 are CZ;
- Z is independently selected from the group consisting of H, halogen, O-alkyl, alkyl and CN;
- R is independently selected from the group consisting of
- and —NR3R4;
- Ra is selected from the group consisting of H and alkyl;
- Rd, Re, Rf, and Rg are H;
- R2 is independently selected from the group consisting of alkyl and —O-alkyl, wherein if two R2 are geminal they can be joined to form a 3 to 6-membered ring;
- R3 and R4 are independently selected from the group consisting of H and alkyl;
- R5 is selected from the group consisting of H and alkyl;
- and
- n is 0, 1, 2, 3 or 4.
17 more elements
A compound selected from the group consisting of:
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.