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US 11,684,603 B2Granted
Neuraminidase inhibition to improve glycocalyx volume and function to ameliorate cardiovascular diseases in pathologies associated with glycocalyx damage
AssigneeCurators of the University of Missouri University
InventorsLuis A. Martinez-Lemus, Christopher A. Foote, Jaume Padilla
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for ameliorating glycocalyx damage by administering a neuraminidase inhibitor. Also disclosed are methods for treating endothelial dysfunction and for improving flow mediated dilation.
Claims15
A method for ameliorating glycocalyx damage in an individual in need thereof, the method comprising:
- administering to the individual in need thereof a composition comprising a neuraminidase inhibitor chosen from Neu5Ac2en ((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid), a Neu5Ac2en derivative, oseltamivir (ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)-cyclohex-1-ene-1-carboxylate), siastatin B ((3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid), a siastatin B analog, a siastatin B derivative, and a sialidase.
A method for treating endothelial dysfunction in an individual in need thereof, the method comprising:
- administering to the individual in need thereof a composition comprising a neuraminidase inhibitor chosen from Neu5Ac2en ((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid), a Neu5Ac2en derivative, oseltamivir (ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)-cyclohex-1-ene-1-carboxylate), siastatin B ((3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid), a siastatin B analog, a siastatin B derivative, and a sialidase.
A method for improving flow mediated dilation in an individual in need thereof, the method comprising:
- administering to the individual in need thereof a composition comprising a neuraminidase inhibitor chosen from Neu5Ac2en ((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid), a Neu5Ac2en derivative, oseltamivir (ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)-cyclohex-1-ene-1-carboxylate), siastatin B ((3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid), a siastatin B analog, a siastatin B derivative, and a sialidase.
Dependencies are inferred from the claim text.