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US 11,684,601 B2Granted
Treatment of cancer with combinations of agents
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJiangbin Ye, Yang Li
Life of this patent
Estimating the term…
Abstract
Methods are provided for the treatment of cancer by administering a combination of metabolic interventions to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.
Claims12
A method for the treatment of neuroblastoma in an individual, the method comprising:
- contacting a population of cancer cells with a synergistically effective amount of (i) isotretinoin;
- and (ii) glyceryltriacetate (GTA), effective to increase differentiation of the cancer cells, wherein the treatment is synergistic relative to the level of differentiation with retinoic acid administered in the absence of GTA.
Dependencies are inferred from the claim text.