Administration of tailored feedstock to increase nitro-containing amphenicol antibiotic susceptibility
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsKatherine L. Akingbade, Christian J. Sund
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Abstract
A method for increasing susceptibility of microorganisms to antibiotics includes providing a microorganism; administering an antibiotic including a nitro-containing amphenicol compound to the microorganism; and administering any of an uronic, aldonic, ulosonic, and aldaric feedstock to the microorganism. The feedstock is adapted to promote cell metabolism, and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitro-containing amphenicol.
Claims17
A method for increasing susceptibility of microorganisms to antibiotics, the method comprising:
- providing a microorganism;
- administering an antibiotic composition comprising a nitro-containing amphenicol compound to the microorganism, wherein the microorganism is susceptible to the nitro-containing amphenicol compound;
- and
- administering a feedstock comprising a sugar acid selected from the group consisting of an uronic, aldonic, ulosonic, and aldaric, or any salt thereof to the microorganism,
- wherein the feedstock is adapted to promote cell metabolism and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitro-containing amphenicol.
A method for increasing susceptibility of microorganisms to antibiotics, the method comprising:
- administering an antibiotic comprising a nitro-containing amphenicol compound to a microorganism, wherein the microorganism is susceptible to the nitro-containing amphenicol compound;
- administering a feedstock comprising a sugar acid selected from the group consisting of uronic, aldonic, ulosonic, and aldaric, or any salt thereof to the microorganism,
- wherein the feedstock is adapted to promote cell metabolism and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitro-containing amphenicol.
An antibiotic composition comprising:
- a nitro-containing amphenicol compound selected from the group consisting of chloramphenicol and azidamfenicol;
- and
- a feedstock comprising a sugar acid selected from the group consisting of an uronic, aldonic, ulosonic, and aldaric, or any salt thereof,
- wherein the feedstock is adapted to promote cell metabolism and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitro-containing amphenicol.
Dependencies are inferred from the claim text.