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US 11,684,587 B2Granted
Composition comprising amino acid polymers and a bioactive agent and method of preparing thereof
AssigneePhagelux (Canada) Inc.
InventorsNancy Tawil, Ramaz Katsarava, David Tugushi, Vakhtang Beridze
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Abstract
A method of treating, reducing or preventing bacterial infection in a wound, the method comprising: applying a film on the wound, the film including a biodegradable polymer with bacteriophages dispersed therein, wherein the polymer is a poly (ester amide urea).
Claims30
A method of treating, reducing or preventing bacterial infection in a wound, the method comprising:
- applying a flexible film on the wound, the film including a biodegradable polymer with bacteriophages dispersed therein, wherein the polymer is a poly (ester amide urea) comprising the following two blocks with random distribution thereof:
- wherein
- the ratio of l:m ranges from 0.01:0.99 to 0.99:0.01, l+m=1,
- R1 is chosen from C1-C12 alkylene optionally interrupted by at least one oxygen, C3-C8 cycloalkylene, C3-C10 cycloalkylalkylene,
- R3 is C1-C12 alkylene,
- R2 and R4 are independently chosen from the side chains of L- and D-amino acids so that the carbon to which R2 or R4 is attached has L or D chirality;
- further comprising gradually delivering at least part of the bacteriophages in the wound at a controlled delivery rate, the controlled delivery rate being controlled by a volume and composition of a wound exudate produced by the wound while the film is applied.
4 more elements
A method of treating, reducing or preventing bacterial infection in a wound, the method comprising:
- applying a flexible film on the wound, the film including bacteriophages dispersed in a biodegradable polymer, wherein the polymer is selected from
- (1) a poly (ester amide urea) wherein at least one diol, at least one diacid, and at least one amino acid are linked together through an ester bond, an amide bond, and a urea bond,
- (2) a poly (ester urethane urea) wherein at least one diol and at least one amino acid are linked together through an ester bond, a urethane bond, and a urea bond,
- (3) a poly (ester amide urethane urea) wherein at least one diol, at least one diacid, and at least one amino acid are linked together through an ester bond, an amide bond, a urethane bond, and a urea bond,
- (4) a poly (ester amide urethane) wherein at least one diol, at least one diacid, and at least one amino acid are linked together through an ester bond, an amide bond, and a urethane bond,
- (5) a poly (ester urea) wherein at least one diol and at least one amino acid are linked together through an ester bond and a urea bond, and
- (6) a poly (ester urethane) wherein at least one diol and at least one amino acid are linked together through an ester bond and a urethane bond,
- further wherein
- the at least one diol is a compound of formula:
- HO—R1—OH, R1 is chosen from C1-C12 alkylene optionally interrupted by at least one oxygen, C3-C8 cycloalkylene, C3-C10 cycloalkylalkylene,
- the at least one diacid is a compound of formula:
- HO—(CO)—R3—(CO)—OH, R3 is C1-C12 alkylene,
- the at least one amino acid is chosen from a naturally occurring amino acid and non-naturally occurring amino acid
- further comprising gradually delivering at least part of the bacteriophages in the wound at a controlled delivery rate, the controlled delivery rate being controlled by a volume and composition of a wound exudate produced by the wound while the film is applied.
11 more elements
Dependencies are inferred from the claim text.