Nanoscale coatings for encapsulation of biological entities
AssigneeThe Regents of the University of California
InventorsInanc Ortac, Gen Yong, Michael Benchimol, Sadik C. Esener
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Abstract
Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.
Claims15
A method of making a bioactive virus delivery device, the method comprising:
- binding an interior polymer material to a virus, wherein the polymer material is bound to the surface of the virus via an electrostatic interaction;
- and
- forming an exterior silica gel matrix directly on the surface of the interior polymer material and virus to envelope, encapsulate, and preserve biological activity of the virus, wherein an outer surface of the silica gel matrix comprises a secondary functionalization, wherein the exterior silica gel matrix does not include the interior polymer material, and wherein encapsulation of the virus by the silica gel matrix protects the virus from immune recognition and neutralization during a viral therapy.
Dependencies are inferred from the claim text.