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US 11,684,584 B2Granted
Branched peg molecules and related compositions and methods
AssigneeGenevant Sciences GmbH
InventorsDebashish Roy, Jean-Rene E. Ella-Menye, Sean D. Monahan, Pierrot Harvie, Anna Galperin, Michael E. Houston, Mary G. Prieve
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Abstract
Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.
Claims10
A pH-sensitive polymer of Formula IXh:
- GalNAc-C5-PEG12- [PEGMA3000.75—HMA0.25] 4.2KDA-[DMAEMA0.36-PAA0.13-BMA0.51]4.93KDa, wherein
- GalNAc is an N-acetylgalactosamine residue;
- C5 is an alkylene group containing 5 carbon atoms;
- PEG12 is a link moiety comprising a polyethylene glycol having 12 ethylene glycol units;
- PEGMA300 is polyethyleneglycol methacrylate residue having 4-5 ethylene glycol units;
- HMA is hexyl methacrylate residue;
- DAEMA is dimethylaminoethyl methacrylate residue;
- PAA is propyl acrylic acid residue;
- and
- BMA is butyl methacrylate residue.
7 more elements
A composition comprising a pH-sensitive polymer of Formula IXh:
- GalNAc-C5-PEG12- [PEGMA3000.75—HMA0.25]4.2KDa-[DMAEMA0.36-PAA0.13-BMA0.51 ]4.93KDa;
- and
- a therapeutic or diagnostic agent,
- wherein
- GalNAc is an N-acetylgalactosamine residue;
- C5 is an alkylene group containing 5 carbon atoms;
- PEG12 is a link moiety comprising a polyethylene glycol having 12 ethylene glycol units;
- PEGMA300 is polyethyleneglycol methacrylate residue having 4-5 ethylene glycol units;
- HMA is hexyl methacrylate residue;
- DAEMA is dimethylaminoethyl methacrylate residue;
- PAA is propyl acrylic acid residue;
- and
- BMA is butyl methacrylate residue.
10 more elements
Dependencies are inferred from the claim text.