Compositions and related methods for targeted drug delivery

An article, comprising:

• a thermoresponsive polymer comprising a polymer backbone, wherein the thermoresponsive polymer is configured to undergo sol-to-gel phase transition from a liquid phase at ambient conditions to a solid or semi-solid phase at physiological conditions;
• a plurality of nanoparticles associated with the polymer, the plurality of nanoparticles comprising one or more therapeutic agents;
• and
• a ligand attached to the polymer comprising a negatively charged functional group under physiological conditions,
• wherein the thermoresponsive polymer has a structure as in:
• wherein:
• x is 0.01-1,
• y is 1-x,
• z is 0.01-1,
• L is a ligand, and
• each R is the same or different and is hydrogen or alkyl.

An article, comprising

• a plurality of nanoparticles comprising a shell and/or a matrix;
• a coating disposed on a surface of the nanoparticle;
• and
• a therapeutic agent encapsulated or embedded within the nanoparticle,
• wherein the shell and/or the matrix comprises albumin and wherein the coating comprises heparin;
• and a thermoresponsive polymer having a structure as in:
• wherein:
• x is 0.01-1,
• y is 1-x,
• z is 0.01-1,
• L is a ligand, and
• each R is the same or different and is hydrogen or alkyl.