Methods for producing carboxylate ligand modified ferric iron hydroxide colloids and related compositions and uses
AssigneeUnited Kingdom Research and Innovation
InventorsJonathan Joseph Powell, Nuno Jorge Rodrigues Faria
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Abstract
Processes for recovering colloids of carboxylate ligand modified ferric iron hydroxide materials such as IHAT (Iron Hydroxide Adipate Tartrate) are described based on the use of water miscible non-aqueous solvents, such as ethanol, methanol and acetone. The processes produce materials with advantageous properties such as improved bioavailability, reduced aggregation and/or agglomeration and/or increased iron content.
Claims30
A composition comprising a carboxylate ligand modified ferric iron hydroxide material having a three dimensional polymeric structure in which the carboxylate ligands are non-stoichiometrically substituted for the oxo or hydroxy groups of the ferric iron hydroxide so that some of the ligand integrates into the solid phase by formal metal-ligand bonding,
- wherein the three dimensional polymeric structure of the carboxylate ligand modified ferric iron hydroxide is such that the substitution of the oxo or hydroxy groups by the carboxylate ligands is random,
- and
- wherein the carboxylate ligand modified ferric iron hydroxide material is produced by a method comprising:
- (i) mixing a colloidal suspension of the carboxylate ligand modified ferric iron hydroxide in a water miscible non-aqueous solvent to cause the carboxylate ligand modified ferric iron hydroxide to agglomerate;
- (ii) recovering the agglomerated carboxylate ligand modified ferric iron hydroxide;
- and
- (iii) drying the carboxylate ligand modified ferric iron hydroxide to produce the carboxylate ligand modified ferric iron hydroxide material;
- wherein the carboxylate ligand comprises one or more dicarboxylate ligands of the formula HOOC—R1—COOH or an ionised form thereof, wherein R1 is an optionally substituted C1-10 alkyl, C1-10 alkenyl or C1-10 alkynyl group;
- and
- wherein the water miscible non-aqueous solvent is selected from ethanol, methanol and/or acetone.
A composition comprising a carboxylate ligand modified ferric iron hydroxide material having a three dimensional polymeric structure in which the carboxylate ligands are non-stoichiometrically substituted for the oxo or hydroxy groups of the ferric iron hydroxide so that some of the ligand integrates into the solid phase by formal metal-ligand bonding,
- wherein the three dimensional polymeric structure of the carboxylate ligand modified ferric iron hydroxide is such that the substitution of the oxo or hydroxy groups by the carboxylate ligands is random, and
- wherein the carboxylate ligand modified ferric iron hydroxide material is produced by a method comprising:
- (i) mixing a colloidal suspension of the carboxylate ligand modified ferric iron hydroxide in a water miscible non-aqueous solvent to cause the carboxylate ligand modified ferric iron hydroxide to agglomerate;
- (ii) recovering the agglomerated carboxylate ligand modified ferric iron hydroxide;
- and
- (iii) drying the carboxylate ligand modified ferric iron hydroxide to produce the carboxylate ligand modified ferric iron hydroxide material;
- wherein the carboxylate ligand comprises one or more dicarboxylate ligands of the formula HOOC—R1—COOH or an ionised form thereof, wherein R1 is an optionally substituted C1-10 alkyl, C1-10 alkenyl or C1-10 alkynyl group;
- and wherein the water miscible non-aqueous solvent is selected from ethanol, methanol and/or acetone;
- and
- wherein on dispersion in water the composition produces a microparticulate ferric iron fraction comprising less than 3.0% of the total ferric iron present in the composition when dispersed in water at a concentration of 40 mM Fe, and the microparticulate ferric iron fraction produced upon dispersion in water is free of aggregates of the carboxylate ligand modified ferric iron hydroxide material.
Dependencies are inferred from the claim text.