Methods of treating eosinophilic esophagitis
AssigneeEllodi Pharmaceuticals, L.P.
InventorsBrian A. Meltzer, Gail M. Comer
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Abstract
The present disclosure provides methods of treating inflammation of the upper gastrointestinal tract, especially the esophagus, by administering an oral corticosteroid. In some cases, the methods include treating eosinophilic esophagitis (EoE) by administering an oral corticosteroid in an induction phase and a maintenance phase to improve peak eosinophilic counts and symptoms. In embodiments, the methods include treating EoE by administering the oral corticosteroid at nighttime and/or while the patient is lying down.
Claims24
A method of topically treating an esophageal stricture in a patient in need thereof with an orally disintegrating tablet comprising about 0.5 mg to about 18 mg of fluticasone or a pharmaceutically acceptable ester thereof, comprising:
- administering the orally disintegrating tablet while the patient is lying down or immediately prior to the patient lying down,
- wherein a therapeutically effective amount of the fluticasone, or pharmaceutically acceptable ester thereof, contacts the esophageal stricture, thereby reducing the severity of the esophageal stricture.
Dependencies are inferred from the claim text.