Apparatus and methods for resecting and/or ablating an undesired tissue

A system for resecting an undesired tissue from a body of a subject, the system comprising:

• a catheter comprising a tip section in a shape of a cylinder's sector having a central longitudinal axis, the tip section comprising:
• a central longitudinal lumen;
• a cutter configured to cut an undesired tissue, said cutter comprising a cutter proximal end;
• a first set of optical fibers configured to transmit laser radiation in a direction parallel to the central longitudinal axis;
• and
• a second set of optical fibers configured to transmit laser radiation, transversely to the central longitudinal axis;
• wherein said cutter proximal end is disposed a select distance distally beyond said second set of optical fibers;
• and
• a processor configured to selectively control at least one parameter of laser radiation transmitted at least by said second set of optical fibers based on a location and/or a 3D image of the undesired tissue, obtained prior to and/or during the resection of the undesired tissue.

A method comprising:

• placing a catheter having a longitudinal axis and a first and a second set of optical fibers near a treatment site, and a cutter comprising a cutter proximal end, wherein said cutter proximal end is disposed a select distance distally beyond said second set of optical fibers;
• activating a laser to transmit laser radiation through the first set of optical fibers to a first area of an undesired tissue in the treatment site, thereby causing non-thermal ablation and/or resection thereof, wherein the radiation is transmitted at a first direction essentially parallel to the longitudinal axis;
• and
• activating a laser to transmit laser radiation through the second set of optical fibers to a second area of the undesired tissue thereby causing thermal or non-thermal ablation thereof, wherein the radiation from the second set of optical fibers is transmitted at a second direction, non-parallel to the first direction;
• and wherein at least one parameter of the laser radiation transmitted by the second optical fiber is controllable.