Chemical ablation formulations and methods of treatments for various diseases
AssigneeNeurotronic, Inc.
InventorLixiao Wang
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.
Claims25
A method of treating a disease, the method comprising:
- inserting a needle-based balloon delivery catheter into a vascular lumen adjacent to a nerve, wherein the needle-based balloon delivery catheter comprises a balloon disposed along an elongated shaft and the balloon has a diameter in an inflated state in a range of from 2 millimeters to 30 millimeters;
- inflating the balloon;
- infusing a chemical formulation at a temperature and at a pressure from the needle-based balloon delivery catheter adjacent to the nerve, wherein an amount of the chemical formulation delivered is effective to injure or damage the nerve to have a benefit of relieving symptoms of the disease, wherein the chemical formulation is at least one of 10 wt % to 100 wt % ethanol and 1 wt % to 100 wt % acetic acid;
- deflating the balloon;
- and
- withdrawing the needle-based balloon delivery catheter from the body lumen, wherein the chemical formulation interacts with the nerve resulting in denervation;
- wherein the disease is chosen from hypertension, diabetes, obesity, end-stage renal disease, heart failure, and a combination thereof.
A method of treating a disease, the method comprising:
- inserting a needle-based balloon delivery catheter into a vascular lumen adjacent to a nerve, wherein the needle-based balloon delivery catheter comprises a balloon disposed along an elongated shaft and the balloon has a diameter in an inflated state in a range of from 2 millimeters to 30 millimeters;
- inflating the balloon;
- infusing a chemical formulation at a temperature and at a pressure from the needle-based balloon delivery catheter adjacent to the nerve, and delivering heat and/or energy from the needle-based balloon delivery catheter adjacent to the nerve, wherein an amount of the heat and/or energy delivered combined with an amount of the chemical formulation delivered is effective to injure or damage the nerve resulting in denervation of the nerve and relief of symptoms of the treated disease, wherein the chemical formulation is at least one of 10 wt % to 100 wt % ethanol and 1 wt % to 100 wt % acetic acid;
- deflating the balloon;
- and
- withdrawing the needle-based balloon delivery catheter from the body lumen;
- wherein the disease is chosen from hypertension, diabetes, obesity, end-stage renal disease, heart failure, and a combination thereof.
Dependencies are inferred from the claim text.