Systems and methods for detecting neurological conditions

#Early detection of neurological conditions, such as Large Vessel Occlusion (LVO) identification may be key to enabling rapid triage and transfer to appropriate care. Computed Tomography Angiography (CTA) is currently used for detecting neurological conditions, but is limited to in-hospital use. Current pre-hospital LVO assessment lack reliability due to training requirements and low inherent accuracies, causing delays in triage, transfer, and treatment. Ultrasound (e.g., transcranial Doppler (TCD) ultrasound) is a reliable diagnostic tool for assessing the presence and severity of LVO, and is non-invasive, inexpensive, and portable. However, a limiting factor is the TCD operator's ability to interpret collected ultrasound data (e.g., Cerebral Blood Flow Velocity (CBFV) waveforms). Such challenges have contributed to TCD being critically underutilized for LVO assessment.

#According to various arrangements, there is provided a tool for determining presence or absence of a neurological condition in a subject. The tool includes an ultrasound device configured to collect ultrasound data from a head of the subject. The tool further includes a processing circuit configured to calculate a curvature metric based on the ultrasound data. The processing circuit is further configured to calculate a velocity asymmetry metric based on the ultrasound data. The processing circuit is further configured to determine presence or absence of the neurological condition in the subject based on the curvature metric and the velocity asymmetry metric.

#In some arrangements, the processing circuit is further configured to compare the curvature metric and the velocity asymmetry metric to a plurality of thresholds.

#Features and aspects of the present disclosure will become apparent from the following description and the accompanying example arrangements shown in the drawings, which are briefly described below.

#FIG. 1 is a schematic diagram illustrating a system for detecting neurological conditions according to various arrangements.

#FIG. 2 is a schematic block diagram illustrating the system (FIG. 1) according to various arrangements.

#The detailed description set forth below in connection with the appended drawings is intended as a description of various configurations and is not intended to represent the only configurations in which the concepts described herein may be practiced. The detailed description includes specific details for providing a thorough understanding of various concepts. However, it will be apparent to those skilled in the art that these concepts may be practiced without these specific details. In some instances, well-known structures and components are shown in block diagram form in order to avoid obscuring such concepts.

#In the following description of various arrangements, reference is made to the accompanying drawings which form a part hereof and in which are shown, by way of illustration, specific arrangements in which the arrangements may be practiced. It is to be understood that other arrangements may be utilized, and structural changes may be made without departing from the scope of the various arrangements disclosed in the present disclosure.

#Arrangements described herein relate to apparatuses, systems, methods, and non-transitory computer-readable media for determining presence of neurological conditions, for example, Large Vessel Occlusion (LVO). For quantifying TCD waveform morphology for the purpose of LVO identification, a diagnostic biomarker measuring curvature of a blood flow velocity waveform has been recently proposed. Further disclosure regarding curvature can be found in non-provisional patent application Ser. No. 16/003,012, titled WAVEFORM VISUALIZATION TOOL FOR FACILITATING MEDICAL DIAGNOSIS, and filed on Jun. 7, 2018, which is incorporated herein by reference in its entirety.