Method for producing objective substance

A method for producing an objective substance, the method comprising:

• producing the objective substance by using a microorganism having an ability to produce the objective substance,
• wherein the microorganism has been modified so that the activity of an S-adenosylmethionine cycle enzyme is increased as compared with a non-modified microorganism,
• wherein the microorganism is a coryneform bacterium,
• wherein the S-adenosylmethionine cycle enzyme is a combination of methionine adenosyltransferase and 5,10-methylenetetrahydrofolate reductase, and optionally may include methionine synthase;
• and
• wherein the objective substance is selected from
• metabolites the biosynthesis of which requires S-adenosylmethionine selected from the group consisting of vanillin, vanillic acid, mugineic acid, ferulic acid, polyamine, guaiacol, 4-vinylguaiacol, 4-ethylguaiacol, creatine, and combinations thereof;
• wherein said producing comprises:
• cultivating the microorganism in a culture medium comprising a carbon source so that the objective substance is produced and accumulates in the culture medium, or
• converting a precursor of the objective substance into the objective substance by:
• cultivating the microorganism in a culture medium comprising the precursor so that the objective substance is produced and accumulates in the culture medium, or
• allowing cells of the microorganism to act on the precursor in a reaction mixture so that the objective substance is produced and accumulates in the reaction mixture.