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US 11,680,270 B2Granted
Recombinant acid-resistant yeast with inhibited lactate metabolism and alcohol production and method of producing lactic acid using the same
AssigneeSK Innovation Co., Ltd.
InventorsJae Yeon Park, Tae Young Lee, Ki Sung Lee
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Abstract
Disclosed is a method of producing lactic acid using a recombinant acid-resistant yeast with inhibited lactate metabolism and alcohol production. More specifically, disclosed are a recombinant acid-resistant yeast in which lactate consumption reaction is reduced and which is imparted with lactic-acid-producing ability to thereby exhibit improved lactic-acid-producing ability and reduced ethanol production, and a method of producing lactic acid using the same.
Claims3
A recombinant strain having lactic-acid-producing ability, in which a gene comprising the nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 encoding an enzyme converting lactate to pyruvate is deleted or attenuated from an acid-resistant yeast strain KCTC13508BP;
- a gene encoding an alcohol dehydrogenase and/or a gene encoding a pyruvate decarboxylase is deleted;
- and
- a gene comprising the nucleotide sequence of SEQ ID NO:
- 7 encoding a lactate dehydrogenase is introduced into the acid-resistant yeast strain.
3 more elements
Dependencies are inferred from the claim text.