Methods of treating disorders using CSF1R inhibitors
AssigneeDeciphera Pharmaceuticals, LLC
InventorsDaniel L. Flynn, Bryan D. Smith, Rodrigo Ruiz Soto, Keisuke Kuida
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Abstract
Described herein are methods of treating cancers and other tumors related to the decreased proliferation, the depletion, or the repolarization of tumor-associated macrophages (TAMs) and treatment of associated disorders, including tenosynovial giant cell tumor (TGCT) and diffuse-type tenosynovial giant cell tumor (DTGCT).
Claims18
A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising orally administering to the patient about 2 mg to about 50 mg of a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof, twice weekly.
A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising orally administering to the patient about 30 mg of a compound represented by the formula:
- twice weekly.
A method of treating tumors known to have expression of the receptor colony-stimulating factor 1 receptor (CSF1R) or its ligands, colony stimulating factor-1 (CSF1) or interleukin (IL)-34, in a patient in need thereof, comprising administering to the patient about 2 mg to about 60 mg of a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof, twice weekly.
Dependencies are inferred from the claim text.