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US 11,679,098 B2Granted
Methods for treating diseases
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsPaula J. Bates, Sarah A. Andres, Joseph A. Burlison, Levi Beverly, Nagaraju Miriyala
Life of this patent
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Abstract
Some embodiments of the invention include methods of using a compound such as Formula (I), Formula (II), or I-1 (e.g., in compositions or in pharmaceutical compositions) for treating diseases (e.g., cancer such as chemo-resistant cancer or cancer-therapy-resistant cancer). Additional embodiments of the invention are also discussed herein.
Claims21
A method for treating an animal for cancer, comprising
- determining a level of MGST1 (microsomal glutathione S-transferase) in a sample comprising cancer cells from the animal having a cancer;
- and
- administering to the animal one or more compositions comprising a compound, if the level of MGST1 in the sample is higher than the level of MGST1 in a control sample,
- wherein (a) determining a level of MGST1 comprises one or more of measuring the extent of expression of MGST1 in the sample, measuring the extent of activity of MGST1 in the sample, or measuring the amount of MGST1 in the sample (b) the compositions may be the same or different if there is more than one administration, (c) the control sample comprises non-cancer cells, and (d) the compound is
- or a salt thereof.
2 more elements
Dependencies are inferred from the claim text.