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US 11,678,989 B2Granted
Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration
AssigneeUniversity of Connecticut
InventorsThanh Duc Nguyen, Ritopa Das
Life of this patent
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Abstract
A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.
Claims19
A method of regenerating bone or tissue, the method comprising:
- applying a scaffold to a wound, the scaffold comprising a plurality of PLLA layers, each layer separated by a hydrogel layer, wherein the PLLA layers comprise a biodegradable nanofiber mesh created by an electrospinning process to exhibit piezoelectricity, wherein the electrospinning process includes rotating a collector drum at a rotation speed between 1,000 and 4,000 RPM, and wherein a piezoelectric constant of the PLLA layers depends at least partially on the rotation speed;
- applying ultrasound energy to the scaffold;
- generating an electrical surface charge on the scaffold;
- and
- delivering an electrical output to the bone or tissue from the scaffold to regenerate the bone or tissue.
2 more elements
A scaffold for regenerating bone or tissue, the scaffold comprising:
- a plurality of PLLA layers comprising a nanofiber mesh, wherein the nanofiber mesh is created by an electrospinning process, and wherein the electrospinning process includes rotating a collector drum at a rotation speed between 1,000 and 4,000 RPM, and wherein the PLLA layers having a piezo constant of 15-20 pC/N resulting at least partially from the rotation speed;
- and
- a plurality of hydrogel layers, each hydrogel layer positioned between two PLLA layers;
- wherein the plurality of PLLA layers deliver an electric charge to the bone or tissue after ultrasound energy is applied to the plurality of PLLA layers to induce growth of the bone or tissue.
1 more element
Dependencies are inferred from the claim text.