Use as rodenticides of compounds that inhibit blood coagulation
OwnerDietrich Gulbainventor
Life of this patent
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Abstract
The invention relates to a use, a method and a poison in which a thrombin inhibitor, a thrombin receptor antagonist, a factor Xa inhibitor, a PAI (plasminogen activator inhibitor), a P2Y12 ADP receptor antagonist or a GPIIb/IIIa receptor antagonist are used as rodenticide.
Claims10
A method of combatting a rodent, the method comprising administering to the rodent a rodenticide comprising at least a factor Xa inhibitor and an antagonist of the ADP receptor P2Y12,
- wherein the inhibitor of factor Xa is a compound of the following formula or a salt or hydrate thereof tolerable for a rodent:
- wherein Q3 is:
- R59 is H, F, CI or Br, R60, R61, R62 and R63 are each independently H, F, Cl, Br, Me, NO2, OH, OMe, NH2, NHAc, NHSO2Me, CH2OH and CH2NH2 and R64 is F, Cl, Br, Me, OH or OMe;
- and
- wherein the antagonist of the ADP receptor P2Y12 is:
- i) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein R94 is H, a halogen, hydroxy or C1-6 alkyl, R95 is H, a halogen, hydroxy, nitro, C1-6 alkyl or C1-6 alkoxy and R96 is H or a halogen;
- ii) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein Y1 is —OR98 or —N(R99)R100, wherein R99 and R100 are each independently H, a halogen or a C1-4 alkyl group and R98 is H or C1-4 alkyl and R97 is H, a halogen or C1-4 alkyl group;
- or
- iii) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein R101 is H, OH, amino, C1 to C4 alkoxy, Aryl-C1-4-alkyloxy, C1-18 alkanoyloxy, C3-6 alkenoyloxy or arylcarbonyloxy, R102 is C1-10 alkanoyl, C3-6 alkenoyl, C4-8 cycloalkylcarbonyl including 3 to 7 ring atoms, substituted benzoyl or 5,6-dihydro-1,4,2-dioxazine-3-yl, Y2 is NH, O or S, R103 is H, a halogen, OH, amino, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or a carboxy group.
A harmful rodent bait comprising at least a rodenticidally effective amount of a factor Xa inhibitor and a rodenticidally effective amount of an antagonist of the ADP receptor P2Y12, wherein the inhibitor of factor Xa is a compound of the following formula or a salt or hydrate thereof tolerable for a rodent:
- wherein Q3 is:
- R59 is H, F, CI or Br, R60, R61, R62 and R63 are each independently H, F, Cl, Br, Me, NO2, OH, OMe, NH2, NHAc, NHSO2Me, CH2OH and CH2NH2 and R64 is F, Cl, Br, Me, OH or OMe;
- and
- wherein the antagonist of the ADP receptor P2Y12 is:
- i) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein R94 is H, a halogen, hydroxy or C1-6 alkyl, R95 is H, a halogen, hydroxy, nitro, C1-6 alkyl or C1-6 alkoxy and R96 is H or a halogen;
- ii) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein Y1 is —OR98 or —N(R99)R100, wherein R99 and R100 are each independently H, a halogen or a C1-4 alkyl group and R98 is H or C1-4 alkyl and R97 is H, a halogen or C1-4 alkyl group;
- or
- iii) a compound of the following formula or a salt or a hydrate thereof tolerable for a rodent:
- wherein R101 is H, OH, amino, C1 to C4 alkoxy, Aryl-C1-4-alkyloxy, C1-18 alkanoyloxy, C3-6 alkenoyloxy or arylcarbonyloxy, R102 is C1-10 alkanoyl, C3-6 alkenoyl, C4-8 cycloalkylcarbonyl including 3 to 7 ring atoms, substituted benzoyl or 5,6-dihydro-1,4,2-dioxazine-3-yl, Y2 is NH, O or S, R103 is H, a halogen, OH, amino, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or a carboxy group.
Dependencies are inferred from the claim text.