Glycophospholipid polymeric network and use thereof

A packaging system for the storage of an ophthalmic device comprising a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked glycophospholipid polymeric networks;

• wherein the one or more crosslinked glycophospholipid polymeric networks comprise a reaction product of one or more glycosaminoglycans having one or more reactive functionality groups, one or more phospholipids having one or more reactive functionality groups and one or more crosslinking agents, wherein the one or more crosslinking agents comprise a bi- or polyfunctional crosslinking agent comprising two or more functional groups that are complementary to the one or more reactive functionality groups of the one or more glycosaminoglycans and the one or more phospholipids, wherein a bond between at least one of the two or more functional groups of the bi- or polyfunctional crosslinking agents and at least one of the one or more reactive functionality groups of the one or more glycosaminoglycans is an ether bond;
• and
• wherein the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

An aqueous ophthalmic composition comprising one or more of crosslinked glycophospholipid polymeric networks, wherein the one or more crosslinked glycophospholipid polymeric networks comprise a reaction product of one or more glycosaminoglycans having one or more reactive functionality groups, one or more phospholipids having one or more reactive functionality groups and one or more first crosslinking agents, wherein the one or more first crosslinking agents comprise a bi- or polyfunctional crosslinking agent comprising two or more functional groups that are complementary to the one or more reactive functionality groups of the one or more glycosaminoglycans and the one or more phospholipids, wherein one of the two or more functional groups of the bi- or polyfunctional crosslinking agent is a glycidyl ether functional group and a bond between the glycidyl ether functional group of the bi- or polyfunctional crosslinking agent and at least one of the one or more reactive functionality groups of the one or more glycosaminoglycans is an ether bond;

• and
• wherein the aqueous ophthalmic composition has an osmolality in a range from about 200 mOsmol/kg to about 400 mOsmol/kg.

A crosslinked glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans having one or more reactive functionality groups, one or more phospholipids having one or more reactive functionality groups and one or more first crosslinking agents, wherein the one or more first crosslinking agents comprise a bi- or polyfunctional crosslinking agent comprising a first and at least a second functional group that are each complementary to the one or more reactive functionality groups of the one or more glycosaminoglycans and the one or more phospholipids, wherein a bond between the first functional group of the bi- or polyfunctional crosslinking agent and one of the at least one or more reactive functionality groups of the one or more glycosaminoglycans is an ether bond, and a bond between the second functional group of the bi- or polyfunctional crosslinking agent and another one of the at least one or more reactive functionality groups of the one or more glycosaminoglycans is an ether bond.