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US 11,673,869 B2Granted
4-oxazolidinone antimicrobial agents
AssigneeNorth Carolina State University
InventorsJoshua G. Pierce, Jonathan J. Mills
Life of this patent
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Abstract
Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.
Claims11
A compound defined by Formula I
- or a pharmaceutically acceptable salt or prodrug thereof, wherein
- X is O;
- R1 is chosen from alkyl, cycloalkyl, and alkylcycloalkyl each optionally substituted with one or more substituents individually chosen from R5;
- R2 is chosen from alkyl, haloalkyl, aryl, cycloalkyl, alkylaryl, and alkylcycloalkyl, each optionally substituted with one or more substituents individually chosen from R5;
- R3 is hydrogen;
- R4 is hydrogen;
- and
- R5 is chosen from hydroxy, halogen, —CN, —NO2, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
- alkylthio;
- haloalkylthio;
- alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloheteroalkyl, alkylaryl, alkylheteroaryl, alkylcycloalkyl, alkylcycloheteroalkyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, and heterodialkylaminocarbonyl.
8 more elements
Dependencies are inferred from the claim text.