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US 11,673,862 B2Granted
Processes to produce brivaracetam
AssigneeSuzhou Pengxu Pharmatech Co., Ltd.
InventorsPeng Wang, Pixu Li, Qiang Wei, Yuanhua Liu
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Abstract
The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.
Claims5
A stereoselective process of making a compound of formula XII (brivaracetam) comprising converting a compound of formula X to the compound of formula XII:
- wherein the converting comprises at least one of the following synthetic routes I and II:
- I. reacting the compound of formula X with (S)-2-aminobutanamide or its salt to produce a compound of formula XI;
- isolating the compound of formula XI, and converting the isolated compound of formula XI to the compound of XII (brivaracetam)
- II. reacting the compound of Formula X with alkyl (S)-2-aminobutanoate to produce a compound of formula XI-a;
- isolating the compound of formula XI-a;
- converting the isolated compound of formula Xl-a to a compound of XII-a;
- isolating the compound of formula XII-a;
- and then converting the isolated compound of XII-a to the compound of formula XII
- wherein R is NH2 or C1-C20 alkoxyl;
- if R is NH2, then XI-a is XI, and XII-a is XII;
- and wherein the process is free of a step of conducting chiral column chromatography purification or chiral HPLC separation of the compound of formula XII.
8 more elements
Dependencies are inferred from the claim text.