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US 11,673,852 B2Granted
Metabolism resistant fenfluramine analogs and methods of using the same
AssigneeZogenix International Limited
InventorsStephen J. Farr, Brooks M. Boyd
Life of this patent
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Abstract
Metabolism-resistant fenfluramine analogs are provided. The subject fenfluramine analogs find use in the treatment of a variety of diseases. For example, methods of treating epilepsy by administering a fenfluramine analog to a subject in need thereof are provided. Also provided are methods of suppressing appetite in a subject in need thereof. Pharmaceutical compositions for use in practicing the subject methods are also provided.
Claims4
A metabolism-resistant fenfluramine analog compound of formula (II):
- wherein:
- R1 is CF3;
- R2, R3, R4, and R5 are each hydrogen
- X1-X5 are each independently H, deuterium, F, alkyl, substituted alkyl;
- and
- n is 1;
- or a salt thereof;
- and
- wherein at least one of X1-X5 is deuterium.
6 more elements
A method of treating a refractory form of epilepsy, comprising:
- orally administering to a patient in need thereof a therapeutically effective amount of a liquid formulation comprising metabolism-resistant fenfluramine analog having a structure of formula (II):
- wherein:
- R1 is CF3;
- R2, R3, R4, and R5 are each hydrogen
- X1-X5 are each independently H, deuterium, F, alkyl, substituted alkyl;
- and
- n is 1;
- or a salt thereof;
- and
- wherein at least one of X1-X5 is deuterium.
7 more elements
Dependencies are inferred from the claim text.