Filter for reducing phenolic compounds from insulin and related infusion and injection devices

A system comprising:

• an injection device comprising
• a housing defining a chamber configured to hold a medicament;
• a displaceable plunger rod disposed at least partially within the housing, an actuator and spring disposed to advance said plunger rod upon actuation of said actuator;
• and
• an outlet in fluid communication with the chamber;
• and
• a filtering device comprising
• a body having at least one inlet and at least one outlet and defining a fluid flow channel provided between the at least one inlet and at least one outlet, the fluid flow channel being in fluid communication with at least one chamber;
• at least one resin disposed in the at least one chamber;
• and
• at least one filter disposed in the fluid flow channel,
• a needle attached to the outlet of said body;
• wherein the outlet of the injection device is attached to the inlet of the filtering device such that the chamber of the injection device is in fluid communication with the fluid flow channel of the filtering device.

A filtering device for removing a preservative from a pharmaceutical composition, the filtering device comprising:

• a body having at least one inlet and at least one outlet and defining a fluid flow channel provided between the at least one inlet and at least one outlet, the fluid flow channel being in fluid communication with at least one chamber;
• at least one resin disposed in the at least one chamber;
• and
• at least one filter disposed in the fluid flow channel, where said filter at least partially removes metal ion excipients from the pharmaceutical composition.

A system comprising:

• an infusion pump comprising
• a housing defining a chamber configured to hold a medicament;
• an outlet in fluid communication with the chamber;
• and
• a filtering device comprising
• a body having at least one inlet and at least one outlet and defining a fluid flow channel provided between the at least one inlet and at least one outlet, the fluid flow channel being in fluid communication with at least one chamber;
• a needle attached to said at least one outlet of said body configured for delivering the medicament;
• at least one resin disposed in the fluid flow channel of said body;
• and
• at least one filter disposed in the fluid flow channel,
• wherein the outlet of the infusion pump is attached to the at least one inlet of the body of the filtering device such that the chamber of the housing of the infusion pump is in fluid communication with the fluid flow channel of the filtering device.