Imageable embolic microsphere
AssigneesBiocompatibles UK Limited, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsMatthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Lennard Lewis, Yiqing Tang
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Abstract
This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
Claims19
A method of making a radiopaque hydrogel bead, comprising:
- forming an activated hydrogel bead by reacting a preformed hydrogel bead with a carbonyldiimidazole or a carbodiimide;
- and
- reacting functional groups on the activated hydrogel bead with an iodinated compound such at the iodinated compound is covalently coupled to the activated hydrogel bead, wherein the iodinated compound is an aromatic iodine containing compound.
Dependencies are inferred from the claim text.