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US 11,672,875 B2Granted
Nanoparticle-alginate gels for X-ray imaging of the vasculature
AssigneeSaint Louis University
InventorsSarah McBride-Gagyi, Steven W. Buckner, Paul Jelliss, Mohammad Salauddin Kader
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Abstract
Disclosed are capped nanoparticles that are effectively trapped within an aqueous gelling solution to produce stable gels and function as a contrast agent for vascular imaging. The contrast agent has good radioopacity, is inexpensive to produce, and is safe to handle. This provides a new method to image the fine vasculature of biological systems.
Claims16
An injectable contrast agent comprising:
- a nanoparticle, the nanoparticle comprising
- a core comprising at least one of a barium sulfate (BaSO4) core, a barium carbonate (BaCO3) core, a calcium carbonate (CaCO3) core and combinations thereof;
- and
- a tetra (ethylene glycol) capping agent;
- and
- a gel precursor solution.
3 more elements
A method for imaging vasculature of a subject, the method comprising:
- introducing into the subject's vasculature an injectable contrast agent, the injectable contrast agent comprising
- a nanoparticle, the nanoparticle comprising
- a core comprising at least one of a barium sulfate (BaSO4) core, a barium carbonate (BaCO3) core, a calcium carbonate (CaCO3) core and combinations thereof;
- and
- a tetra (ethylene glycol) capping agent;
- and
- a gel precursor solution, wherein the nanoparticle is dispersed in the gel precursor solution;
- and
- imaging the subject using an X-ray technique.
6 more elements
Dependencies are inferred from the claim text.