Anticancer trail-targeted plant virus particles
AssigneeCase Western Reserve University
InventorNicole F. Steinmetz
Life of this patent
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Abstract
An agent is described that includes a plant virus particle or VLP conjugate to TRAIL. Associating TRAIL with the plant virus particle or VLP serves to both target cancer cells and induce their apoptosis. The agent can therefore be used for a method of treating cancer in a subject.
Claims12
An agent comprising a potato virus X (PVX) plant virus particle or virus-like particle (VLP) non-covalently conjugated to at least one tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) by a non-covalent bond selected from coordination bonds between nickel-coordinated nitrilotriacetic acid (Ni-NTA) modules displayed on the PVX plant virus particle or VLP outer surface and a histidine-tag on TRAIL.
Dependencies are inferred from the claim text.