Methods of treating aging-related disorders
AssigneeHCW Biologics, Inc.
InventorHing Wong
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of treating an aging-related disease or condition in a subject in need thereof, killing or reducing the number of senescent cells in a subject in need thereof, improving the texture and/or appearance of skin and/or hair in a subject in need thereof, and assisting in the treatment of obesity in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more natural killer (NK) cell activating agent(s) and/or a therapeutically effective number of activated NK cells.
Claims46
A method of treating a cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a multi-chain chimeric polypeptide comprising:
- (a) a first chimeric polypeptide comprising:
- (i) a first target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 188;
- (ii) a soluble tissue factor domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 93;
- and
- (iii) a first domain of a pair of affinity domains, wherein the first domain of the pair of the affinity domains comprises a sequence that is at least 90% identical to SEQ ID NO:
- 115;
- and
- (b) a second chimeric polypeptide comprising:
- (i) a second domain of the pair of affinity domains, wherein the second domain of the pair of affinity domains comprises a sequence that is at least 90% identical to SEQ ID NO:
- 113;
- and
- (ii) a second target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 188,
- wherein the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains.
A method of killing or reducing the number of senescent cells in a subject having a cancer, the method comprising administering to the subject a therapeutically effective amount of a multi-chain chimeric polypeptide comprising:
- (a) a first chimeric polypeptide comprising:
- (i) a first target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 188;
- (ii) a soluble tissue factor domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 93;
- and
- (iii) a first domain of a pair of affinity domains, wherein the first domain of the pair of the affinity domains comprises a sequence that is at least 90% identical to SEQ ID NO:
- 115;
- and
- (b) a second chimeric polypeptide comprising:
- (i) a second domain of the pair of affinity domains, wherein the second domain of the pair of affinity domains comprises a sequence that is at least 90% identical to SEQ ID NO:
- 113;
- and
- (ii) a second target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
- 188,
- wherein the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains.
Dependencies are inferred from the claim text.