Materials and methods for suppressing and/or treating bone related diseases and symptoms
AssigneesIndiana University Research and Technology Corporation, University of Rochester, The United States of America as Represented by the Department of Veteranas Affairs
InventorsTeresita M. Bellido, G. David Roodman, Jesus Delgado-Calle, Robert K. Boeckman, Frank H. Ebetino
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Abstract
Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.
Claims5
A compound, comprising:
- A-Y—B,
- wherein:
- A is
- and X is selected from the group consisting of:
- H and
- Y is a linker of formula NR1;
- R′ is H, CH3, alkyl, halogen, CF3, CN, OH, OCH3, or O-alkyl;
- wherein R1 is NR2R3, NR2S(═O)2R3 or R2OR3;
- R2 and R3 are independently selected from H, C1-C10 alkyl, C1-C10 alkoxy, C6H5OR4, and wherein R2 and R3 are not both H,
- R4 is C1-C10 alkyl, C1-C10 alkoxy, carbonyl, or amide;
- and
- B is at least one bisphosphonate optionally substituted with OH, halogen, CH3, NH2,
- or a pharmaceutically acceptable salt thereof.
A compound comprising one or more stereoisomers of the formula:
- wherein:
- ′R is H, CH3, alkyl, halogen, CF3, CN, OH, OCH3, or O-alkyl;
- n is 1-9;
- m is 0-7;
- and
- X is H, OH, halogen, CH3, NH2, N-alkyl, or N-dialkyl;
- or a pharmaceutically acceptable salt.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.