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US 11,672,776 B2Granted
Multi-arm polymeric alkanoate conjugates
AssigneeNektar Therapeutics
InventorsAntoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
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Abstract
Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
Claims12
A multi-arm polymer conjugate having the following structure,
- wherein:
- POLY1 is —(CH2CH2O)a—;
- X is a covalent bond;
- R1, in each occurrence, is independently selected from the group consisting of H, methyl, ethyl, propyl, n-butyl, isopropyl, isobutyl, a halide, a nitrile, —NO2, and —CF3;
- n is an integer from 1 to 7;
- a ranges from 40 to 500;
- and
- D is a residue of a hydroxyl-containing taxane or a hydroxyl-containing camptothecin having a molecular weight of less than about 800 daltons, where the attachment to D is at a hydroxyl oxygen.
5 more elements
Dependencies are inferred from the claim text.