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US 11,668,702 B2Granted
Regulation of fungal fruiting body development
AssigneeThe Chinese University of Hong Kong
InventorsJinhui Chang, Hoi Shan Kwan, Man Chun Wong, Po Lam Chan, Yichun Xie, Wing Chee Beatrice Ho
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Abstract
The present invention provides for a fungus, especially in the form of fungal mycelium, that has altered glycogen synthase kinase-3 (GSK-3) expression and/or activity level and therefore exhibits modified characteristics in fruiting body development. Also provided are compositions and methods for generating living fungal mycelium with altered fruiting body development.
Claims10
A method for regulating fungal fruiting body development in a basidiomycetous fungus, comprising:
- (1) administering to the fungus an inhibitor of glycogen synthase kinase-3 (GSK-3);
- or
- (2) administering to the fungus an siRNA, a dsRNA, a microRNA, a miniRNA, a lncRNA, or an antisense oligonucleotide targeting GSK-3 genomic sequence in the fungus,
- thereby inhibiting GSK-3 activity in the fungus and delaying or preventing fugal fruiting body development in the fungus when compared with a control fungus not having its GSK-3 activity inhibited.
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