Methods and devices related to controlled delivery of phages as a theranostic tool
AssigneeThe Board of Trustees of The University of Alabama
InventorsAsma Hatoum, Shreyas Rao
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Abstract
Disclosed herein is an engineered bacteriophage comprising an indicator gene, wherein said indicator gene is an RNA aptamer or a green fluorescent protein (GFP) or GFP-like protein, and further wherein said indicator gene can indicate the presence of a microorganism, such as a bacterial infection. The engineered bacteriophage can be capable of infecting and killing the microorganism. The engineered microorganism can be in a composition for delivery to a subject, and can be in hyaluronic acid, for example. Also disclosed are methods of using the engineered bacteriophage to diagnose and/or treat a subject with a bacterial infection.
Claims17
An engineered lytic staphylococcal bacteriophage comprising an indicator gene, wherein said indicator gene is an RNA aptamer, and further wherein said indicator gene can indicate a presence of a target of interest.
A composition comprising:
- a) an engineered lytic staphylococcal bacteriophage comprising an indicator gene, wherein said indicator gene is an RNA aptamer, and further wherein said indicator gene can indicate presence of a target of interest;
- and
- b) hyaluronic acid (HA), wherein said engineered bacteriophage is encapsulated within said HA.
Dependencies are inferred from the claim text.