Steroid derivative FXR agonist
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsHaiying He, Hualing Xiao, Peng Li, Chunyan Du, Zhi Luo, Shuhui Chen
Life of this patent
Estimating the term…
Abstract
The present invention relates to a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to applications thereof in the preparation of drugs for treating FXR related diseases.
Claims20
A compound represented by formula (III),
- wherein,
- ring A is selected from 5- to 12-membered aryl, 5- to 12-membered heteroaryl, 5_to 6-membered non-aromatic heterocyclyl, or 5- to 6-membered cycloalkyl;
- and said ring A is optionally substituted with 1, 2 or 3 of R;
- L is selected from C1-6 alkyl, C1-6 heteroalkyl, or C2-6 alkenyl, and said L is optionally substituted with 1, 2 or 3 of R;
- R is selected from F, Cl, Br, I, OH, CN, NO2, NH2, C1-3 all ylamino;
- N,N-di(C1-3 alkyl)amino, C1-3 alkyl, C1-3 alkyloxy, or C1-3 alkylthio, and said R is optionally substituted with 1, 2 or 3 R′;
- R′ is selected from F, Cl, Br, I, OH, NH2, NO2, CN, COOH, Me, Et, CH2F, CHF2, CF3, CH3O, CH3S, NH(CH3), or N(CH3)2;
- said “hetero” represents heteroatom or heteroatomic group, selected from —C(═O)NH—, N, —NH—, —C(═NH)—, —S(═O)2NH—, —S(═O)NH—, —O—, —S—, ═O, ═S, —C(═O)C—, —C(═O)—, —C(═S)—, —S(═O)—, —S(═O)2—, or —NHC(═O)NH—;
- in any of the above cases, the number of the heteroatom or heteroatomic groups is independently selected from 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof.
The compound or the pharmaceutically acceptable salt thereof according to claim wherein ring A is selected from phenyl, pyridyl, pyridin-2(1H)-onyl, pyrimidyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, thienyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, isoxazolyl, isothiazolyl, bicyclo[1.1.1]pentyl, benzoxazolyl, benzo[d]isoxazolyl, indazolyl, indolyl, quinolinyl, isoquinolinyl, quinazolinyl, 1H-pyrrolo[2,3-B]pyridyl, indolizinyl benzothiazoyl or benzothienyl, and said ring A is optionally substituted with 1, 2 or 3 of R.
Dependencies are inferred from the claim text.