Mitoketoscins: mitochondrial-based therapeutics targeting ketone metabolism in cancer cells
AssigneeLunella Biotech, Inc.
InventorsMichael P. Lisanti, Federica Sotgia
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Abstract
The present disclosure relates to compounds that bind to at least one of ACAT1/2 and OXCT1/2 and inhibit mitochondrial ATP production, referred to herein as mitoketoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoketoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoketoscins to provide anti-aging benefits. Specific mitoketoscin compounds are also disclosed.
Claims6
A pharmaceutical composition comprising, as an active ingredient, a compound having the general formula:
- wherein each R may be the same or different and is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, carboxyl, alkanes, cyclic alkanes, alkenes, cyclic alkenes, alkynes, ketones, aldehydes, carboxylic acids, ethers, esters, amines, amides, monocyclic or polycyclic arene, heteroarenes, phenols, and benzoic acid;
- and a pharmaceutically acceptable carrier or excipient;
- wherein the concentration of the active ingredient is sufficient to inhibit the formation of MCF7 mammospheres in a human tumor, wherein the pharmaceutically acceptable carrier or excipient comprises at least one of sodium alginate, agar powder, laminalia powder, sodium hydrogen carbonate, calcium carbonate, fatty acid esters of polyoxyethylene sorbitan, sodium laurylsulfate, a monoglyceride of stearic acid, and lactose.
A pharmaceutical composition comprising, as an active ingredient, a compound having the general formula:
- wherein each R may be the same or different and is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, carboxyl, alkanes, cyclic alkanes, alkenes, cyclic alkenes, alkynes, ketones, aldehydes, carboxylic acids, ethers, esters, amines, amides, monocyclic or polycyclic arene, heteroarenes, phenols, and benzoic acid;
- and
- a pharmaceutically acceptable carrier or excipient;
- wherein the concentration of the active ingredient is sufficient to inhibit the formation of MCF7 mammospheres in a human tumor;
- and
- wherein the pharmaceutical composition is in a form selected from the group comprising a tablet, a pill, a powder, and a capsule.
Dependencies are inferred from the claim text.